Journal article
Quantifying epileptogenesis in rats with spontaneous and responsive brain state dynamics.
Dakota N Crisp, Warwick Cheung, Stephen V Gliske, Alan Lai, Dean R Freestone, David B Grayden, Mark J Cook, William C Stacey
Brain Communications | Oxford University Press | Published : 2020
Abstract
There is a crucial need to identify biomarkers of epileptogenesis that will help predict later development of seizures. This work identifies two novel electrophysiological biomarkers that quantify epilepsy progression in a rat model of epileptogenesis. The long-term tetanus toxin rat model was used to show the development and remission of epilepsy over several weeks. We measured the response to periodic electrical stimulation and features of spontaneous seizure dynamics over several weeks. Both biomarkers showed dramatic changes during epileptogenesis. Electrically induced responses began to change several days before seizures began and continued to change until seizures resolved. These chan..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was funded by the National Health and Medical Research Council Project Grant (1065638) (M.J.C., D.B.G. and D.R.F.), the Rackham Graduate Student Research Grant (D.N.C. and W.C.S.), the National Institutes of Health K01-ES026839 (S.V.G.) and R01-NS094399 (W.C.S.), the Melbourne International Fee Remission Scholarship (W.C.), the Melbourne International Research Scholarship (W.C.) and Michigan Medicine (Robbins Family Research Fund and Lucas Family Research Fund) (W.C.S.).